Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals.
Identifieur interne : 000321 ( Main/Exploration ); précédent : 000320; suivant : 000322Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals.
Auteurs : Jaclyn M. Goodrich [États-Unis] ; Yi Wang ; Brenda Gillespie ; Robert Werner ; Alfred Franzblau ; Niladri BasuSource :
- Toxicology and applied pharmacology [ 1096-0333 ] ; 2011.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Composés méthylés du mercure (effets indésirables), Composés méthylés du mercure (urine), Dentistes (MeSH), Exposition professionnelle (effets indésirables), Femelle (MeSH), Glutathione S-transferase pi (génétique), Glutathione S-transferase pi (urine), Glutathione transferase (génétique), Glutathione transferase (urine), Humains (MeSH), Marqueurs biologiques (urine), Mercure (effets indésirables), Mercure (urine), Michigan (épidémiologie), Mâle (MeSH), Personnel dentaire (MeSH), Poils (composition chimique), Poils (effets des médicaments et des substances chimiques), Polymorphisme génétique (effets des médicaments et des substances chimiques), Polymorphisme génétique (génétique), Sélénoprotéines (génétique), Sélénoprotéines (urine).
- MESH :
- composition chimique : Poils.
- effets des médicaments et des substances chimiques : Poils, Polymorphisme génétique.
- effets indésirables : Composés méthylés du mercure, Exposition professionnelle, Mercure.
- génétique : Glutathione S-transferase pi, Glutathione transferase, Polymorphisme génétique, Sélénoprotéines.
- urine : Composés méthylés du mercure, Glutathione S-transferase pi, Glutathione transferase, Marqueurs biologiques, Mercure, Sélénoprotéines.
- épidémiologie : Michigan.
- Adulte, Adulte d'âge moyen, Dentistes, Femelle, Humains, Mâle, Personnel dentaire.
English descriptors
- KwdEn :
- Adult (MeSH), Biomarkers (urine), Dental Staff (MeSH), Dentists (MeSH), Female (MeSH), Glutathione S-Transferase pi (genetics), Glutathione S-Transferase pi (urine), Glutathione Transferase (genetics), Glutathione Transferase (urine), Hair (chemistry), Hair (drug effects), Humans (MeSH), Male (MeSH), Mercury (adverse effects), Mercury (urine), Methylmercury Compounds (adverse effects), Methylmercury Compounds (urine), Michigan (epidemiology), Middle Aged (MeSH), Occupational Exposure (adverse effects), Polymorphism, Genetic (drug effects), Polymorphism, Genetic (genetics), Selenoproteins (genetics), Selenoproteins (urine).
- MESH :
- chemical , adverse effects : Mercury, Methylmercury Compounds.
- chemical , genetics : Glutathione S-Transferase pi, Glutathione Transferase, Selenoproteins.
- chemical , urine : Biomarkers, Glutathione S-Transferase pi, Glutathione Transferase, Mercury, Methylmercury Compounds, Selenoproteins.
- geographic , epidemiology : Michigan.
- adverse effects : Occupational Exposure.
- chemistry : Hair.
- drug effects : Hair, Polymorphism, Genetic.
- genetics : Polymorphism, Genetic.
- Adult, Dental Staff, Dentists, Female, Humans, Male, Middle Aged.
Abstract
Mercury is a potent toxicant of concern to both the general public and occupationally exposed workers (e.g., dentists). Recent studies suggest that several genes mediating the toxicokinetics of mercury are polymorphic in humans and may influence inter-individual variability in mercury accumulation. This work hypothesizes that polymorphisms in key glutathione synthesizing enzyme, glutathione S-transferase, and selenoprotein genes underlie inter-individual differences in mercury body burden as assessed by analytical mercury measurement in urine and hair, biomarkers of elemental mercury and methylmercury, respectively. Urine and hair samples were collected from a population of dental professionals (n=515), and total mercury content was measured. Average urine (1.06±1.24 microg/L) and hair mercury levels (0.49±0.63 microg/g) were similar to national U.S. population averages. Taqman assays were used to genotype DNA from buccal swab samples at 15 polymorphic sites in genes implicated in mercury metabolism. Linear regression modeling assessed the ability of polymorphisms to modify the relationship between mercury biomarker levels and exposure sources (e.g., amalgams, fish consumption). Five polymorphisms were significantly associated with urine mercury levels (GSTT1 deletion), hair mercury levels (GSTP1-105, GSTP1-114, GSS 5'), or both (SEPP1 3'UTR). Overall, this study suggests that polymorphisms in selenoproteins and glutathione-related genes may influence elimination of mercury in the urine and hair or mercury retention following exposures to elemental mercury (via dental amalgams) and methylmercury (via fish consumption).
DOI: 10.1016/j.taap.2011.09.014
PubMed: 21967774
PubMed Central: PMC3324924
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals.</title><author><name sortKey="Goodrich, Jaclyn M" sort="Goodrich, Jaclyn M" uniqKey="Goodrich J" first="Jaclyn M" last="Goodrich">Jaclyn M. Goodrich</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name></author><author><name sortKey="Gillespie, Brenda" sort="Gillespie, Brenda" uniqKey="Gillespie B" first="Brenda" last="Gillespie">Brenda Gillespie</name></author><author><name sortKey="Werner, Robert" sort="Werner, Robert" uniqKey="Werner R" first="Robert" last="Werner">Robert Werner</name></author><author><name sortKey="Franzblau, Alfred" sort="Franzblau, Alfred" uniqKey="Franzblau A" first="Alfred" last="Franzblau">Alfred Franzblau</name></author><author><name sortKey="Basu, Niladri" sort="Basu, Niladri" uniqKey="Basu N" first="Niladri" last="Basu">Niladri Basu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21967774</idno><idno type="pmid">21967774</idno><idno type="doi">10.1016/j.taap.2011.09.014</idno><idno type="pmc">PMC3324924</idno><idno type="wicri:Area/Main/Corpus">000301</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000301</idno><idno type="wicri:Area/Main/Curation">000301</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000301</idno><idno type="wicri:Area/Main/Exploration">000301</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals.</title><author><name sortKey="Goodrich, Jaclyn M" sort="Goodrich, Jaclyn M" uniqKey="Goodrich J" first="Jaclyn M" last="Goodrich">Jaclyn M. Goodrich</name><affiliation wicri:level="2"><nlm:affiliation>Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name></author><author><name sortKey="Gillespie, Brenda" sort="Gillespie, Brenda" uniqKey="Gillespie B" first="Brenda" last="Gillespie">Brenda Gillespie</name></author><author><name sortKey="Werner, Robert" sort="Werner, Robert" uniqKey="Werner R" first="Robert" last="Werner">Robert Werner</name></author><author><name sortKey="Franzblau, Alfred" sort="Franzblau, Alfred" uniqKey="Franzblau A" first="Alfred" last="Franzblau">Alfred Franzblau</name></author><author><name sortKey="Basu, Niladri" sort="Basu, Niladri" uniqKey="Basu N" first="Niladri" last="Basu">Niladri Basu</name></author></analytic><series><title level="j">Toxicology and applied pharmacology</title><idno type="eISSN">1096-0333</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Biomarkers (urine)</term><term>Dental Staff (MeSH)</term><term>Dentists (MeSH)</term><term>Female (MeSH)</term><term>Glutathione S-Transferase pi (genetics)</term><term>Glutathione S-Transferase pi (urine)</term><term>Glutathione Transferase (genetics)</term><term>Glutathione Transferase (urine)</term><term>Hair (chemistry)</term><term>Hair (drug effects)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Mercury (adverse effects)</term><term>Mercury (urine)</term><term>Methylmercury Compounds (adverse effects)</term><term>Methylmercury Compounds (urine)</term><term>Michigan (epidemiology)</term><term>Middle Aged (MeSH)</term><term>Occupational Exposure (adverse effects)</term><term>Polymorphism, Genetic (drug effects)</term><term>Polymorphism, Genetic (genetics)</term><term>Selenoproteins (genetics)</term><term>Selenoproteins (urine)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Composés méthylés du mercure (effets indésirables)</term><term>Composés méthylés du mercure (urine)</term><term>Dentistes (MeSH)</term><term>Exposition professionnelle (effets indésirables)</term><term>Femelle (MeSH)</term><term>Glutathione S-transferase pi (génétique)</term><term>Glutathione S-transferase pi (urine)</term><term>Glutathione transferase (génétique)</term><term>Glutathione transferase (urine)</term><term>Humains (MeSH)</term><term>Marqueurs biologiques (urine)</term><term>Mercure (effets indésirables)</term><term>Mercure (urine)</term><term>Michigan (épidémiologie)</term><term>Mâle (MeSH)</term><term>Personnel dentaire (MeSH)</term><term>Poils (composition chimique)</term><term>Poils (effets des médicaments et des substances chimiques)</term><term>Polymorphisme génétique (effets des médicaments et des substances chimiques)</term><term>Polymorphisme génétique (génétique)</term><term>Sélénoprotéines (génétique)</term><term>Sélénoprotéines (urine)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Mercury</term><term>Methylmercury Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glutathione S-Transferase pi</term><term>Glutathione Transferase</term><term>Selenoproteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Biomarkers</term><term>Glutathione S-Transferase pi</term><term>Glutathione Transferase</term><term>Mercury</term><term>Methylmercury Compounds</term><term>Selenoproteins</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Michigan</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Hair</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Poils</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hair</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Poils</term><term>Polymorphisme génétique</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Composés méthylés du mercure</term><term>Exposition professionnelle</term><term>Mercure</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glutathione S-transferase pi</term><term>Glutathione transferase</term><term>Polymorphisme génétique</term><term>Sélénoprotéines</term></keywords><keywords scheme="MESH" qualifier="urine" xml:lang="fr"><term>Composés méthylés du mercure</term><term>Glutathione S-transferase pi</term><term>Glutathione transferase</term><term>Marqueurs biologiques</term><term>Mercure</term><term>Sélénoprotéines</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Michigan</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Dental Staff</term><term>Dentists</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dentistes</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Personnel dentaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mercury is a potent toxicant of concern to both the general public and occupationally exposed workers (e.g., dentists). Recent studies suggest that several genes mediating the toxicokinetics of mercury are polymorphic in humans and may influence inter-individual variability in mercury accumulation. This work hypothesizes that polymorphisms in key glutathione synthesizing enzyme, glutathione S-transferase, and selenoprotein genes underlie inter-individual differences in mercury body burden as assessed by analytical mercury measurement in urine and hair, biomarkers of elemental mercury and methylmercury, respectively. Urine and hair samples were collected from a population of dental professionals (n=515), and total mercury content was measured. Average urine (1.06±1.24 microg/L) and hair mercury levels (0.49±0.63 microg/g) were similar to national U.S. population averages. Taqman assays were used to genotype DNA from buccal swab samples at 15 polymorphic sites in genes implicated in mercury metabolism. Linear regression modeling assessed the ability of polymorphisms to modify the relationship between mercury biomarker levels and exposure sources (e.g., amalgams, fish consumption). Five polymorphisms were significantly associated with urine mercury levels (GSTT1 deletion), hair mercury levels (GSTP1-105, GSTP1-114, GSS 5'), or both (SEPP1 3'UTR). Overall, this study suggests that polymorphisms in selenoproteins and glutathione-related genes may influence elimination of mercury in the urine and hair or mercury retention following exposures to elemental mercury (via dental amalgams) and methylmercury (via fish consumption).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21967774</PMID><DateCompleted><Year>2012</Year><Month>01</Month><Day>09</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0333</ISSN><JournalIssue CitedMedium="Internet"><Volume>257</Volume><Issue>2</Issue><PubDate><Year>2011</Year><Month>Dec</Month><Day>01</Day></PubDate></JournalIssue><Title>Toxicology and applied pharmacology</Title><ISOAbbreviation>Toxicol Appl Pharmacol</ISOAbbreviation></Journal><ArticleTitle>Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals.</ArticleTitle><Pagination><MedlinePgn>301-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.taap.2011.09.014</ELocationID><Abstract><AbstractText>Mercury is a potent toxicant of concern to both the general public and occupationally exposed workers (e.g., dentists). Recent studies suggest that several genes mediating the toxicokinetics of mercury are polymorphic in humans and may influence inter-individual variability in mercury accumulation. This work hypothesizes that polymorphisms in key glutathione synthesizing enzyme, glutathione S-transferase, and selenoprotein genes underlie inter-individual differences in mercury body burden as assessed by analytical mercury measurement in urine and hair, biomarkers of elemental mercury and methylmercury, respectively. Urine and hair samples were collected from a population of dental professionals (n=515), and total mercury content was measured. Average urine (1.06±1.24 microg/L) and hair mercury levels (0.49±0.63 microg/g) were similar to national U.S. population averages. Taqman assays were used to genotype DNA from buccal swab samples at 15 polymorphic sites in genes implicated in mercury metabolism. Linear regression modeling assessed the ability of polymorphisms to modify the relationship between mercury biomarker levels and exposure sources (e.g., amalgams, fish consumption). Five polymorphisms were significantly associated with urine mercury levels (GSTT1 deletion), hair mercury levels (GSTP1-105, GSTP1-114, GSS 5'), or both (SEPP1 3'UTR). Overall, this study suggests that polymorphisms in selenoproteins and glutathione-related genes may influence elimination of mercury in the urine and hair or mercury retention following exposures to elemental mercury (via dental amalgams) and methylmercury (via fish consumption).</AbstractText><CopyrightInformation>Copyright © 2011 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Goodrich</LastName><ForeName>Jaclyn M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yi</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Gillespie</LastName><ForeName>Brenda</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Werner</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Franzblau</LastName><ForeName>Alfred</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Basu</LastName><ForeName>Niladri</ForeName><Initials>N</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UL1 RR024986-01</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T42 OH008455</GrantID><Acronym>OH</Acronym><Agency>NIOSH CDC HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>2T42 OH 008455-04</GrantID><Acronym>OH</Acronym><Agency>NIOSH CDC HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1RR024986</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 ES007062-20</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 ES017885</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 ES007062</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 RR024986</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 007062</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>09</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Toxicol Appl Pharmacol</MedlineTA><NlmUniqueID>0416575</NlmUniqueID><ISSNLinking>0041-008X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008767">Methylmercury Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051140">Selenoproteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.5.1.-</RegistryNumber><NameOfSubstance UI="C413545">glutathione S-transferase T1</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.5.1.18</RegistryNumber><NameOfSubstance UI="C496556">GSTP1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.5.1.18</RegistryNumber><NameOfSubstance UI="D051549">Glutathione S-Transferase pi</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.5.1.18</RegistryNumber><NameOfSubstance UI="D005982">Glutathione Transferase</NameOfSubstance></Chemical><Chemical><RegistryNumber>FXS1BY2PGL</RegistryNumber><NameOfSubstance UI="D008628">Mercury</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003797" MajorTopicYN="Y">Dental Staff</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003815" MajorTopicYN="Y">Dentists</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051549" MajorTopicYN="N">Glutathione S-Transferase pi</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005982" MajorTopicYN="N">Glutathione Transferase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006197" MajorTopicYN="N">Hair</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008628" MajorTopicYN="N">Mercury</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008767" MajorTopicYN="N">Methylmercury Compounds</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008824" MajorTopicYN="N" Type="Geographic">Michigan</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016273" MajorTopicYN="N">Occupational Exposure</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051140" MajorTopicYN="N">Selenoproteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>06</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>09</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>09</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>10</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>10</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>1</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21967774</ArticleId><ArticleId IdType="pii">S0041-008X(11)00367-X</ArticleId><ArticleId IdType="doi">10.1016/j.taap.2011.09.014</ArticleId><ArticleId IdType="pmc">PMC3324924</ArticleId><ArticleId IdType="mid">NIHMS328201</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Am Dent Assoc. 2010 Apr;141(4):391-9</Citation><ArticleIdList><ArticleId IdType="pubmed">20354088</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Environ Occup Health. 2005 Jan-Feb;60(1):17-23</Citation><ArticleIdList><ArticleId IdType="pubmed">16961004</ArticleId></ArticleIdList></Reference><Reference><Citation>Cent Eur J Public Health. 2009 Mar;17(1):36-40</Citation><ArticleIdList><ArticleId IdType="pubmed">19418718</ArticleId></ArticleIdList></Reference><Reference><Citation>PCR Methods Appl. 1995 Jun;4(6):357-62</Citation><ArticleIdList><ArticleId IdType="pubmed">7580930</ArticleId></ArticleIdList></Reference><Reference><Citation>Fundam Appl Toxicol. 1985 Oct;5(5):816-31</Citation><ArticleIdList><ArticleId IdType="pubmed">4065458</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2006 Feb;114(2):297-301</Citation><ArticleIdList><ArticleId IdType="pubmed">16451871</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Med Genet B Neuropsychiatr Genet. 2007 Oct 5;144B(7):885-90</Citation><ArticleIdList><ArticleId IdType="pubmed">17503480</ArticleId></ArticleIdList></Reference><Reference><Citation>FASEB J. 2007 Oct;21(12):3063-74</Citation><ArticleIdList><ArticleId IdType="pubmed">17536041</ArticleId></ArticleIdList></Reference><Reference><Citation>Toxicology. 2007 May 20;234(3):145-56</Citation><ArticleIdList><ArticleId IdType="pubmed">17408840</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Environ Health. 1972 Aug;25(2):77-91</Citation><ArticleIdList><ArticleId IdType="pubmed">5045067</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Total Environ. 2007 Oct 15;385(1-3):37-47</Citation><ArticleIdList><ArticleId IdType="pubmed">17716707</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health. 2005;4:20</Citation><ArticleIdList><ArticleId IdType="pubmed">16202128</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Res. 2009 Aug;109(6):786-96</Citation><ArticleIdList><ArticleId IdType="pubmed">19515364</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2010 Mar;118(3):437-43</Citation><ArticleIdList><ArticleId IdType="pubmed">20194072</ArticleId></ArticleIdList></Reference><Reference><Citation>Twin Res Hum Genet. 2006 Aug;9(4):501-6</Citation><ArticleIdList><ArticleId IdType="pubmed">16899157</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Environ Health. 2004 Nov;59(11):588-95</Citation><ArticleIdList><ArticleId IdType="pubmed">16599007</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1997 Apr 11;272(15):10004-12</Citation><ArticleIdList><ArticleId IdType="pubmed">9092542</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Ind Med. 2007 Oct;50(10):757-64</Citation><ArticleIdList><ArticleId IdType="pubmed">17477364</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2004 Aug;112(11):1165-71</Citation><ArticleIdList><ArticleId IdType="pubmed">15289161</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Rev Toxicol. 2006 Sep;36(8):609-62</Citation><ArticleIdList><ArticleId IdType="pubmed">16973445</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2008 Jun;116(6):734-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18560528</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Environ Health. 1976 Nov-Dec;31(6):302-9</Citation><ArticleIdList><ArticleId IdType="pubmed">999343</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Total Environ. 2010 Dec 1;409(1):70-7</Citation><ArticleIdList><ArticleId IdType="pubmed">20952048</ArticleId></ArticleIdList></Reference><Reference><Citation>Occup Environ Med. 1994 Apr;51(4):287</Citation><ArticleIdList><ArticleId IdType="pubmed">8199675</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Total Environ. 2010 Nov 15;408(24):6079-85</Citation><ArticleIdList><ArticleId IdType="pubmed">20875913</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Res. 2007 Feb;103(2):191-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16890218</ArticleId></ArticleIdList></Reference><Reference><Citation>Antioxid Redox Signal. 2009 Nov;11(11):2631-40</Citation><ArticleIdList><ArticleId IdType="pubmed">19453253</ArticleId></ArticleIdList></Reference><Reference><Citation>Environ Health Perspect. 2009 Nov;117(11):1767-72</Citation><ArticleIdList><ArticleId IdType="pubmed">20049130</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li></region></list><tree><noCountry><name sortKey="Basu, Niladri" sort="Basu, Niladri" uniqKey="Basu N" first="Niladri" last="Basu">Niladri Basu</name><name sortKey="Franzblau, Alfred" sort="Franzblau, Alfred" uniqKey="Franzblau A" first="Alfred" last="Franzblau">Alfred Franzblau</name><name sortKey="Gillespie, Brenda" sort="Gillespie, Brenda" uniqKey="Gillespie B" first="Brenda" last="Gillespie">Brenda Gillespie</name><name sortKey="Wang, Yi" sort="Wang, Yi" uniqKey="Wang Y" first="Yi" last="Wang">Yi Wang</name><name sortKey="Werner, Robert" sort="Werner, Robert" uniqKey="Werner R" first="Robert" last="Werner">Robert Werner</name></noCountry><country name="États-Unis"><region name="Michigan"><name sortKey="Goodrich, Jaclyn M" sort="Goodrich, Jaclyn M" uniqKey="Goodrich J" first="Jaclyn M" last="Goodrich">Jaclyn M. Goodrich</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SuicidDentistV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000321 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000321 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SuicidDentistV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:21967774
|texte= Glutathione enzyme and selenoprotein polymorphisms associate with mercury biomarker levels in Michigan dental professionals.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21967774" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SuicidDentistV1
| This area was generated with Dilib version V0.6.39. |  |